MersV1, Main, Exploration, bibRecord, 000913

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

Identifieur interne : 000913 ( Main/Exploration ); précédent : 000912; suivant : 000914

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

Auteurs : Vineet D. Menachery ; Alexandra Sch Fer ; Kristin E. Burnum-Johnson ; Hugh D. Mitchell ; Amie J. Eisfeld ; Kevin B. Walters ; Carrie D. Nicora ; Samuel O. Purvine ; Cameron P. Casey ; Matthew E. Monroe ; Karl K. Weitz ; Kelly G. Stratton ; Bobbie-Jo M. Webb-Robertson ; Lisa E. Gralinski ; Thomas O. Metz ; Richard D. Smith ; Katrina M. Waters ; Amy C. Sims ; Yoshihiro Kawaoka [États-Unis, Japon] ; Ralph S. Baric

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2018.

RBID : PMC:5798318

Descripteurs français

English descriptors

KwdEn :
- Animals, Antigen Presentation, Antigenic Variation, Cell Line, Chlorocebus aethiops, DNA Methylation, Dogs, Down-Regulation, Epigenesis, Genetic, Histones (chemistry), Humans, Influenza A Virus, H5N1 Subtype (pathogenicity), Madin Darby Canine Kidney Cells, Major Histocompatibility Complex, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Mutation, Open Reading Frames, Proteomics, Vero Cells.
MESH :
- chemical , chemistry : Histones.
- pathogenicity : Influenza A Virus, H5N1 Subtype, Middle East Respiratory Syndrome Coronavirus.
- Animals, Antigen Presentation, Antigenic Variation, Cell Line, Chlorocebus aethiops, DNA Methylation, Dogs, Down-Regulation, Epigenesis, Genetic, Humans, Madin Darby Canine Kidney Cells, Major Histocompatibility Complex, Mutation, Open Reading Frames, Proteomics, Vero Cells.

Abstract

Significance

Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798318

DOI: 10.1073/pnas.1706928115
PubMed: 29339515
PubMed Central: 5798318

Affiliations:

Le document en format XML

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<affiliation><nlm:aff id="aff1">Department of Microbiology and Immunology,<institution>University of Texas Medical Branch</institution>
, Galveston,<addr-line>TX</addr-line>
 77555;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
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<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
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, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
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 99354;</nlm:aff>
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 53706;</nlm:aff>
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 53706;</nlm:aff>
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 99354;</nlm:aff>
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 99354;</nlm:aff>
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 99354;</nlm:aff>
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 99354;</nlm:aff>
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<author><name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M." last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name>
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 99354;</nlm:aff>
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 27599;</nlm:aff>
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 99354;</nlm:aff>
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 99354;</nlm:aff>
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, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
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 53706;</nlm:aff>
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;</nlm:aff>
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, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>
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 27599</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape</title>
<author><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
<affiliation><nlm:aff id="aff1">Department of Microbiology and Immunology,<institution>University of Texas Medical Branch</institution>
, Galveston,<addr-line>TX</addr-line>
 77555;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
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<author><name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E." last="Burnum-Johnson">Kristin E. Burnum-Johnson</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D." last="Mitchell">Hugh D. Mitchell</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name>
<affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>
, Madison,<addr-line>WI</addr-line>
 53706;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Walters, Kevin B" sort="Walters, Kevin B" uniqKey="Walters K" first="Kevin B." last="Walters">Kevin B. Walters</name>
<affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>
, Madison,<addr-line>WI</addr-line>
 53706;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nicora, Carrie D" sort="Nicora, Carrie D" uniqKey="Nicora C" first="Carrie D." last="Nicora">Carrie D. Nicora</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Purvine, Samuel O" sort="Purvine, Samuel O" uniqKey="Purvine S" first="Samuel O." last="Purvine">Samuel O. Purvine</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Casey, Cameron P" sort="Casey, Cameron P" uniqKey="Casey C" first="Cameron P." last="Casey">Cameron P. Casey</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Monroe, Matthew E" sort="Monroe, Matthew E" uniqKey="Monroe M" first="Matthew E." last="Monroe">Matthew E. Monroe</name>
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, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Weitz, Karl K" sort="Weitz, Karl K" uniqKey="Weitz K" first="Karl K." last="Weitz">Karl K. Weitz</name>
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, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G." last="Stratton">Kelly G. Stratton</name>
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, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M." last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name>
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, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. Metz</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D." last="Smith">Richard D. Smith</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name>
<affiliation><nlm:aff id="aff3"><institution>Biological Sciences Division, Pacific Northwest National Laboratory</institution>
, Richland,<addr-line>WA</addr-line>
 99354;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
<affiliation><nlm:aff id="aff4">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine,<institution>University of Wisconsin–Madison</institution>
, Madison,<addr-line>WI</addr-line>
 53706;</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Madison (Wisconsin)</settlement>
<region type="state">Wisconsin</region>
</placeName>
<orgName type="university" n="3">Université du Wisconsin à Madison</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science,<institution>University of Tokyo</institution>
, Tokyo 113-8654,<country>Japan</country>
;</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
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</placeName>
<orgName type="university" n="3">Université de Tokyo</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6">International Research Center for Infectious Diseases, Institute of Medical Science,<institution>University of Tokyo</institution>
, Tokyo 113-8654,<country>Japan</country>
;</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="province">Région de Kantō</region>
</placeName>
<orgName type="university" n="3">Université de Tokyo</orgName>
</affiliation>
</author>
<author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<affiliation><nlm:aff id="aff2">Department of Epidemiology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599;</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff7">Microbiology and Immunology,<institution>University of North Carolina at Chapel Hill</institution>
, Chapel Hill,<addr-line>NC</addr-line>
 27599</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2018">2018</date>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antigen Presentation</term>
<term>Antigenic Variation</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>DNA Methylation</term>
<term>Dogs</term>
<term>Down-Regulation</term>
<term>Epigenesis, Genetic</term>
<term>Histones (chemistry)</term>
<term>Humans</term>
<term>Influenza A Virus, H5N1 Subtype (pathogenicity)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Major Histocompatibility Complex</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Mutation</term>
<term>Open Reading Frames</term>
<term>Proteomics</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Cellules Vero</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Complexe majeur d'histocompatibilité</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Histone ()</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Mutation</term>
<term>Méthylation de l'ADN</term>
<term>Protéomique</term>
<term>Présentation d'antigène</term>
<term>Régulation négative</term>
<term>Sous-type H5N1 du virus de la grippe A (pathogénicité)</term>
<term>Variation des antigènes</term>
<term>Épigenèse génétique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Histones</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term>
<term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Sous-type H5N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Antigen Presentation</term>
<term>Antigenic Variation</term>
<term>Cell Line</term>
<term>Chlorocebus aethiops</term>
<term>DNA Methylation</term>
<term>Dogs</term>
<term>Down-Regulation</term>
<term>Epigenesis, Genetic</term>
<term>Humans</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Major Histocompatibility Complex</term>
<term>Mutation</term>
<term>Open Reading Frames</term>
<term>Proteomics</term>
<term>Vero Cells</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cadres ouverts de lecture</term>
<term>Cellules Vero</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Complexe majeur d'histocompatibilité</term>
<term>Histone</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Mutation</term>
<term>Méthylation de l'ADN</term>
<term>Protéomique</term>
<term>Présentation d'antigène</term>
<term>Régulation négative</term>
<term>Variation des antigènes</term>
<term>Épigenèse génétique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Both highly pathogenic avian influenza virus and Middle East respiratory syndrome coronavirus (MERS-CoV) infections are characterized by severe disease and high mortality. The continued threat of their emergence from zoonotic populations underscores an important need to understand the dynamics of their infection. By comparing the host responses across other related respiratory virus infections, these studies have identified a common avenue used by MERS-CoV and A/influenza/Vietnam/1203/2004 (H5N1-VN1203) influenza to antagonize antigen presentation through epigenetic modulation. Overall, the use of cross-comparisons provides an additional approach to leverage systems biology data to identify key pathways and strategies used by viruses to subvert host immune responses and may be critical in developing both vaccines and therapeutic treatment.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mandl, Jn" uniqKey="Mandl J">JN Mandl</name>
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</biblStruct>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morse, Ss" uniqKey="Morse S">SS Morse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sawyer, Sl" uniqKey="Sawyer S">SL Sawyer</name>
</author>
<author><name sortKey="Elde, Nc" uniqKey="Elde N">NC Elde</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avgousti, Dc" uniqKey="Avgousti D">DC Avgousti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marazzi, I" uniqKey="Marazzi I">I Marazzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lewandowska Polak, A" uniqKey="Lewandowska Polak A">A Lewandowska-Polak</name>
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</analytic>
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<biblStruct><analytic><author><name sortKey="Pancham, K" uniqKey="Pancham K">K Pancham</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tenland, E" uniqKey="Tenland E">E Tenland</name>
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<biblStruct><analytic><author><name sortKey="Siezen, Cl" uniqKey="Siezen C">CL Siezen</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Heller, Nm" uniqKey="Heller N">NM Heller</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Zissler, Um" uniqKey="Zissler U">UM Zissler</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
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<biblStruct><analytic><author><name sortKey="Chakrabarti, Ak" uniqKey="Chakrabarti A">AK Chakrabarti</name>
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<biblStruct><analytic><author><name sortKey="Sarmento, L" uniqKey="Sarmento L">L Sarmento</name>
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<author><name sortKey="Afonso, Cl" uniqKey="Afonso C">CL Afonso</name>
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<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name>
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<biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Tynell, J" uniqKey="Tynell J">J Tynell</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Summerfield, A" uniqKey="Summerfield A">A Summerfield</name>
</author>
<author><name sortKey="Mccullough, Kc" uniqKey="Mccullough K">KC McCullough</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perrone, La" uniqKey="Perrone L">LA Perrone</name>
</author>
<author><name sortKey="Plowden, Jk" uniqKey="Plowden J">JK Plowden</name>
</author>
<author><name sortKey="Garcia Sastre, A" uniqKey="Garcia Sastre A">A García-Sastre</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
<author><name sortKey="Tumpey, Tm" uniqKey="Tumpey T">TM Tumpey</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hatta, Y" uniqKey="Hatta Y">Y Hatta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rimmelzwaan, Gf" uniqKey="Rimmelzwaan G">GF Rimmelzwaan</name>
</author>
<author><name sortKey="Katz, Jm" uniqKey="Katz J">JM Katz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alshukairi, An" uniqKey="Alshukairi A">AN Alshukairi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Smale, St" uniqKey="Smale S">ST Smale</name>
</author>
<author><name sortKey="Tarakhovsky, A" uniqKey="Tarakhovsky A">A Tarakhovsky</name>
</author>
<author><name sortKey="Natoli, G" uniqKey="Natoli G">G Natoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lieberman, Pm" uniqKey="Lieberman P">PM Lieberman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seo, Yl" uniqKey="Seo Y">YL Seo</name>
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<author><name sortKey="Heo, S" uniqKey="Heo S">S Heo</name>
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<biblStruct><analytic><author><name sortKey="Verweij, Mc" uniqKey="Verweij M">MC Verweij</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Aevermann, Bd" uniqKey="Aevermann B">BD Aevermann</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcdermott, Je" uniqKey="Mcdermott J">JE McDermott</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
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<biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name>
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<biblStruct><analytic><author><name sortKey="Gibbs, Dl" uniqKey="Gibbs D">DL Gibbs</name>
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<biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
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</analytic>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Matzke, Mm" uniqKey="Matzke M">MM Matzke</name>
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</div1>
</back>
</TEI>
<affiliations><list><country><li>Japon</li>
<li>États-Unis</li>
</country>
<region><li>Région de Kantō</li>
<li>Wisconsin</li>
</region>
<settlement><li>Madison (Wisconsin)</li>
<li>Tokyo</li>
</settlement>
<orgName><li>Université de Tokyo</li>
<li>Université du Wisconsin à Madison</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S." last="Baric">Ralph S. Baric</name>
<name sortKey="Burnum Johnson, Kristin E" sort="Burnum Johnson, Kristin E" uniqKey="Burnum Johnson K" first="Kristin E." last="Burnum-Johnson">Kristin E. Burnum-Johnson</name>
<name sortKey="Casey, Cameron P" sort="Casey, Cameron P" uniqKey="Casey C" first="Cameron P." last="Casey">Cameron P. Casey</name>
<name sortKey="Eisfeld, Amie J" sort="Eisfeld, Amie J" uniqKey="Eisfeld A" first="Amie J." last="Eisfeld">Amie J. Eisfeld</name>
<name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E." last="Gralinski">Lisa E. Gralinski</name>
<name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D." last="Menachery">Vineet D. Menachery</name>
<name sortKey="Metz, Thomas O" sort="Metz, Thomas O" uniqKey="Metz T" first="Thomas O." last="Metz">Thomas O. Metz</name>
<name sortKey="Mitchell, Hugh D" sort="Mitchell, Hugh D" uniqKey="Mitchell H" first="Hugh D." last="Mitchell">Hugh D. Mitchell</name>
<name sortKey="Monroe, Matthew E" sort="Monroe, Matthew E" uniqKey="Monroe M" first="Matthew E." last="Monroe">Matthew E. Monroe</name>
<name sortKey="Nicora, Carrie D" sort="Nicora, Carrie D" uniqKey="Nicora C" first="Carrie D." last="Nicora">Carrie D. Nicora</name>
<name sortKey="Purvine, Samuel O" sort="Purvine, Samuel O" uniqKey="Purvine S" first="Samuel O." last="Purvine">Samuel O. Purvine</name>
<name sortKey="Sch Fer, Alexandra" sort="Sch Fer, Alexandra" uniqKey="Sch Fer A" first="Alexandra" last="Sch Fer">Alexandra Sch Fer</name>
<name sortKey="Sims, Amy C" sort="Sims, Amy C" uniqKey="Sims A" first="Amy C." last="Sims">Amy C. Sims</name>
<name sortKey="Smith, Richard D" sort="Smith, Richard D" uniqKey="Smith R" first="Richard D." last="Smith">Richard D. Smith</name>
<name sortKey="Stratton, Kelly G" sort="Stratton, Kelly G" uniqKey="Stratton K" first="Kelly G." last="Stratton">Kelly G. Stratton</name>
<name sortKey="Walters, Kevin B" sort="Walters, Kevin B" uniqKey="Walters K" first="Kevin B." last="Walters">Kevin B. Walters</name>
<name sortKey="Waters, Katrina M" sort="Waters, Katrina M" uniqKey="Waters K" first="Katrina M." last="Waters">Katrina M. Waters</name>
<name sortKey="Webb Robertson, Bobbie Jo M" sort="Webb Robertson, Bobbie Jo M" uniqKey="Webb Robertson B" first="Bobbie-Jo M." last="Webb-Robertson">Bobbie-Jo M. Webb-Robertson</name>
<name sortKey="Weitz, Karl K" sort="Weitz, Karl K" uniqKey="Weitz K" first="Karl K." last="Weitz">Karl K. Weitz</name>
</noCountry>
<country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
</region>
</country>
<country name="Japon"><region name="Région de Kantō"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
</region>
<name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name>
</country>
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</affiliations>
</record>

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Serveur d'exploration MERS

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

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